【摘要】 目的：探讨腹腔镜胆囊切除术对胆囊结石患者血清C反应蛋白（CRP）和白细胞介素6（IL-6）水平的影响分析。方法：回顾性分析2014年4月-2016年4月于本院收治胆囊结石患者100例，根据手术方式不同将其分为腹腔镜组及开腹组，各50例。开腹组给予常规开腹胆囊切除术治疗，腹腔镜组给予腹腔镜胆囊切除术治疗，统计分析两组患者治疗前后血清CRP、IL-6水平变化、免疫球蛋白变化及治疗效果情况。结果：腹腔镜组患者手术时间、术中出血量、肛门排气时间及住院时间均少于开腹组，差异均有统计学意义（P<0.05）；腹腔镜组患者治疗后血清CRP、IL-6水平均低于开腹组，差异均有统计学意义（P<0.05）；腹腔镜组患者治疗后血清免疫球蛋白A、免疫球蛋白G、免疫球蛋白M（IgA、IgG、IgM）水平均高于开腹组，差异均有统计学意义（P<0.05）。结论：腹腔镜胆囊切除术对胆囊结石患者有显著临床效果，对患者机体炎症反应、细胞免疫功能几乎无影响，更有利于患者术后康复，值得临床
应用。
【关键词】 腹腔镜胆囊切除术； 胆囊结石； CRP； IL-6
Effect Analysis of Laparoscopic Cholecystectomy on Serum CRP and IL-6 Levels of Patients with Gallbladder Stone/LI Pinggao.//Medical Innovation of China，2018，15（07）：056-059
【Abstract】 Objective：To discuss the effect analysis of laparoscopic cholecystectomy on serum CRP and IL-6 levels of patients with gallbladder stone. Method：100 patients with gallbladder stone were retrospectively analyzed from April 2014 to April 2016 in our hospital.According to different operation methods，all patients were divided into the experimental group（50 cases） and the control group（50 cases）， the control group was given conventional laparotomy cholecystectomy treatment，the experimental group was given laparoscopic cholecystectomy treatment.The changes of serum CRP and IL-6 levels，immune globulin，treatment effect of two groups were analyzed.Result：The operation time，intraoperative blood loss，anal exhaust time and hospital stay of the experimental group were significantly lower than those of the control groupthe differences were statistically significant（P<0.05）.After treatment，the serum levels of CRP，IL-6 of the experimental group were significantly lower than those of the control group，the differences were statistically significant（P<0.05）.The levels of IgA，IgG，IgM in the experimental group were significantly higher than those of the control group，the differences were statistically significant （P<0.05）.Conclusion：Laparoscopic cholecystectomy in patients with gallbladder stone has significant clinical effect，does not affect inflammation，cell immune function，it is more beneficial to postoperative rehabilitation，it’s worth for further clinical promotion.
【Key words】 Laparoscopic cholecystectomy； Gallbladder stone； CRP； IL-6
First-author’s address：Shantou Chaonan Minsheng Hospital，Shantou 515144 ，China
doi：10.3969/j.issn.1674-4985.2018.07.016
膽囊结石是普通外科常见疾病之一，我国成年人发病率约10%[1-2]，主要表现为恶食油腻、右腹部及左肩部疼痛，临床上一般采用保守内科治疗和外科手术治疗两种方式，结石较小的患者可选择保守治疗，结石较大而保守治疗无效或有阻塞则需要外科手术治疗，传统的开腹胆囊切除创伤较大、恢复慢及并发症多，腹腔镜胆囊切除切口小，但术中人工气腹也可能造成机体有一定的损伤[3-4]。本研究通过对比腹腔镜胆囊切除术与开腹胆囊切除术对胆囊结石患者术后的机体炎症反应及免疫功能的变化情况，而得知两者对机体炎症反应及免疫功能的影响，现报道如下。